OUR ON-GOING STUDIES

STRIVE 002

STRIVE 002 is an international, prospective observational study designed to strengthen global understanding of severe acute infections in hospitalized adults. The study uses an innovative master protocol approach allowing multiple related observational studies to be conducted...

IC-SARI (STRIVE 002A):

One of the study-specific appendices under STRIVE 002 is the IC-SARI study (STRIVE 002A). This is a multicenter, multinational, prospective cohort study focusing on a particularly vulnerable population

STRIVE 002: An International Observational Study of Adults with Acute Infection

SICRA Set to Launch Participant Enrollment for the Global STRIVE 002 Observational Study at Lira

STRIVE 002 is an international, prospective observational study designed to strengthen global understanding of severe acute infections in hospitalized adults. The study uses an innovative master protocol approach, allowing multiple related observational studies to be conducted under a single, harmonized framework. The master protocol outlines the overarching objectives, governance, and standardized study procedures, while study-specific appendices describe individual research questions that build on this common platform. STRIVE 002 supports investigations across a wide range of infectious syndromes, including:

• Acute respiratory infections

• Infections outside the respiratory tract

• Established infectious diseases

• Emerging and re-emerging infectious threats

Study Overview

STRIVE 002 enrolls adults hospitalized with an acute infection. Clinical data and biological specimens are collected prospectively, with the overarching goal of advancing knowledge on the epidemiology, clinical course, and biological mechanisms of severe infections that contribute significantly to global morbidity and mortality.

The protocol was developed by the Strategies and Treatments for Respiratory Infections and Viral Emergencies (STRIVE) Network and is being implemented across multiple international sites. In Uganda, the study will be conducted at three sites, including the Strengthening Institutional Capacity for Research Administration (SICRA) site, underscoring Uganda’s growing role in high-impact global infectious disease research.

Participating sites are affiliated with research networks funded by the United States National Institutes of Health (NIH) and the U.S. Department of Veterans Affairs, ensuring rigorous scientific oversight and international collaboration.

STRIVE 002A

Study Focus

IC-SARI enrolls immunocompromised adults admitted to hospital with severe acute respiratory infection (SARI). Using the STRIVE observational framework, the study aims to generate high-quality data on the pathogens, host factors, and outcomes associated with SARI in immunocompromised populations worldwide.

Study Objectives

The primary goal of IC-SARI is to advance understanding of:

• The pathogens most commonly causing SARI among immunocompromised adults globally

• The clinical outcomes associated with these infections

Specific objectives include:

1. Describing the distribution of pathogens causing SARI among hospitalized immunocompromised adults
2. Characterizing the spectrum of immunocompromising conditions in this population
3. Describing clinical outcomes:
a. Overall
b. By type of immunocompromising condition
c. By detected pathogen
d. By key host factors
e. Study Population

Participants enrolled in IC-SARI must meet eligibility criteria outlined in the STRIVE 002 master protocol, in addition to study-specific criteria. In brief, the study includes adults with moderate-to-severe immunocompromising conditions who are hospitalized with SARI.

Through participation in STRIVE 002 and IC-SARI, the SICRA site contributes to a global effort to generate evidence that will inform clinical care, preparedness, and response for severe infectious diseases—particularly among high-risk populations.